Figure 2: Individual HDL-C responses to n-3 FA supplementation and exercise for middle-aged men. The subjects exercised for 60 minutes at 55- 60 maximal heart rate followed by 2 weeks fish oil supplementation (0.9g n-3 FA), followed by the same amount and intensity as the initial bout of exercise. HDL-C values reported are the baseline values compared to the values after n-3 FA supplementation and both bouts of exercise. Data are reported as means ± SE, n=7 for older middle-aged men. There was a significant increase of 17.1% (P<0.001) from pre-exericse: pre-supplementation to postexercise: post-supplementation. Each subject’s HDL-C levels increased due to the supplementation and exercise. * signifies the hyper-responder who increased his HDL-C by 43%.