Author Study type N Chemotherapy RE Disease Control* (%) Median PFS (months) Toxicity** (%) Van Hazel Dose escalation 25 Irinotecan (50-100 mg/m2) Whole liver 87 6.0 28 Lim Prospective registry 30 Bolus 5-FU Whole liver 60 5.3 23 Hendlisz Phase III 23 23 5-FU (225-300 mg/m2) 5-FU (300 mg/m2) Whole liver N/A 86 35 4.5 2.1 4 26 Chua Case series 140 5-FU 225 mg/m2 Involved lobe(s) 63 NR NR Cohen Dose escalation 21 Capecitabine (375-1000 mg/m2) Lobar 95 NR* 17 *Defined as sum of percentage of patients with complete response, partial response, or stable disease **Defined as either grade 3/4 or serious non-hematological toxicity

Table 1: Summary of combination radioembolization and chemotherapy trials for refractory metastatic colorectal cancer