Study (reference) |
Patients |
Regimen |
CR |
Toxicity
Grade 3 |
|
Kent E, et al [14] |
24 |
RT 60Gy ÷ 30 fractions+ gemcitabine MTD 10-30mg/m2 twice weekly |
91% |
Hepatic: 3 patient
Diarrhea: 1 patient
Neutropenia: 1 patient |
|
Caffo O, et al. [17] |
16 |
RT 54Gy ÷ 30 fractions+
gemcitabine
MTD 400mg/m2 weekly+ cisplatin 100mg/m2 q 3wks |
100% |
NA |
|
Sangar VK, et al. [18] |
8 |
RT 52.5Gy ÷ 20 fractions +gemcitabine
MTD 150mg/m2 once weekly |
88% |
Cystitis: 1 patient
Diarrhea: 1 patient |
|
Present study |
32 |
RT 65Gy ÷35 fractions +gemcitabine
100mg/m2 weekly |
69.2% |
Diarrhea: 6 patients
Nausea and vomiting: 5 patients
Neutropenia: 1 patient
Thrombocytopenia: 2 patient
Cystitis: 1 patient |
