| Parameters |
Hypofractionation Cohort |
| number of patients |
130 |
| treatment interval |
1967-1977 |
| mean ageat radiation (range) |
54 (27-77) years |
| at first analysis, 1994 |
73 (50-97) years |
| at last analysis, 2011 |
76 (50-98) years |
| T stage pT1/2/3/4 |
28/58/10/4% |
| N stagepN+/pN0 |
43/57% |
| follow up (FU) time |
|
| mean / median (range), in years: |
|
| all |
28.1 / 26.6 (7.2-43.6) |
| lost of FU cohort (death, moved; 33%) |
18.7 / 18.2 (7.2-27) * |
| known dead of disease (DOD, 2%) |
at 18.5 and 25.6 years |
| INED (33%) |
30.8 / 29.5 (20-38.9) |
| ANED (63%) |
27.1/23.7 (7.2-43.6) |
| ANED, still alive (06/2011, 15%) |
39.6 / 40.6 (38.3-42.5) |
| 6-10 years FU |
7% |
| >10-20 years FU |
28% |
| >20-30 years FU |
59% |
| >30 years FU |
6% |
| previous breast surgery |
|
| (mostly radical) mastectomy |
98% |
| breast conserving |
2% |
| hypofractionation schedules, 3f/w |
|
| [BED2GY, α/β=2/α/β=3, 5f/w] |
|
| 13x 3.3Gy= 42.9Gy[56/54Gy] |
124 |
| 12x 3.3Gy= 39.6Gy[52/50Gy] |
2 |
| 15x 3.3Gy= 49.5Gy[66/62Gy] |
2 |
| 14x 3.3Gy= 46.2Gy[61/58Gy] |
1 |
| 14x 3.5Gy= 49.0Gy[68/64Gy] |
1 |
| allive with known disease |
|
| at first analysis, 1994 |
0, 1 |
| at last analysis, 2011 |
2, 5 |
* 3 patients were alive with disease when last time seen, all others
ANED; Loss of follow up was in most patients due to emigration to
other countries; ANED: Alive and No Evidence of Disease when last
time seen; AD: Alive with Disease when last time seen; DOD: Died of
Disease; INED: Inter-currently died, No Evidence of Disease |
