FRACTIONATION Author [ref] Year Treatment Interval Follow up years (range) n pat Dose/Session (Gy) Total Dose (GY) ~BED2Gy a/b=2Gy/3Gy % BPN [grade] Interval to BPN mean (range)   [33] 1996 1958-1962 na (na - 2.5) 33 4.58 55 90/83 73% [1-3] 0.5-2.5 y           84 4.25 51 80/74 15% [1-3] 0.5-2 y   [14] 1987 1980-1983 na (na - 7) 250 3.4 51 69/66 2.4% [1 and 3] 0.3-2 y H  [31] 1990 1982-1984 na (3-5.5) 338 3 45 56/54 5.90% (1-4 year)    [9] 1995 1981-NA median 8 (2-11) 113 2.67 40 47/46 0% 0    [26] 1995 1981-NA median 8 (1-11) 334 2.67 40 47/46 0% 0 Y [32] 1997 1979-1986 median 12.5 (na) 164 2.19 35 37/36 0% 0   [29] 2000 1963-1965 (na - 34) 71 4 44 66/62 63% [1-4] 4.2y (<1-19 y   [24] 2000 1989-1992 alive: median 5.9 (na - 10) 1148 2.66 40 47/46 0% 0 P [27]* 2002 1984-1999 (na - 10) 89 6 30 60/55 0% [2-4] 0    [25] 2004 1980-1993 median 7.3 (2.5-18) 332 2.6 52 60/58 14% [1-4] >/=G3: 0.8%/ y   [1] 2008 1999-2002 median 5.1 (max. 8.0) 119 3.2 42 54/52 0.1%[1] 2y O [2] 2008 1999-2001 median 6 (max. 8.0) 74 2.67 40 47/46 0 0   [3] 2013 1999-2002 median 9.3 (max. 12.4) 193 3.20 or 2.67 41.6/40 54/52;47/46 none mentioned 0   own study 2014 1967-1977 median 26.6 (7-45.2) 124 3.3 43 56/54 1% [2] 25y   [30] 1992 19968-1985 median 6.6 (<1-19) 1117 2 50 50 1.8% [1-2] 10 months (1.5-77) N [13] 1993 1982-1990 median 4 128 2   50 9%/5% [1/3 no latency O  [31] 1990 1982-1984 (3-5.5) 111 1.8 54 51 1% [?] (1-4 years) R [28] 1990 1977-1985 median 10 697 2 50 50 <1% [na] na M  [1] 2008 1999-2002 median 5.1 (max. 8.0) 309 2 50 50 0% 0 O  [2] 2008 1999-2001 median 6 (max. 8.0) 153 2 50 50 0% 0   [3] 2013 1999-2002 median 9.3 (max. 12.4) 462 2 50 50 none mentioned 0 *postoperative axillary radiation after axillary melanoma metastasis dissection, 2 fractions/week.

Table 3: Selected published data on the rate of brachial plexus neuropathy (BPN) following differently fractionated radiation therapy of the breast and axillary ± supraclavicular region.