Author

N

Method

Treatment

Endpoint

Comment

Chang

130

IHC

50.4 Gy 5-
FU+LV

TRG

No correlation

Sturm

66

IHC

45 Gy Heat
 shock hypertermia 5-FU+LV

TNM downstaging

No correlation

Lin

70

IHC

45 Gy +/- 5-FU

TNM downstaging

Lack of p53 expression associated with poor response

Bertolini

91

IHC

50 Gy 5-FU

TRG; TNM
 Downstaging; DFS;OS

No correlation

Kudrimoti

17

IHC

50.4-59.4 Gy 5-
FU

pCR vs. PR

No correlation

Jakob

22

IHC

50.4 5-FU

TRG

No correlation

Terzi

37

IHC

45 Gy 5-FU

TRG; TNM
 downstaging

No correlation

Negri

57

IHC

40-45 Gy +/- 5-
FU +Oxa

pCR

No correlation

Moral

39

IHC

42 Gy 5-FU +
 LV

TNM downstaging

No correlation

Huerta

38

IHC

50.4 Gy
 Capecitabine

Tumor size

No correlation

IHC: Immunochemistry; 5-FU: 5-fluoruracil; LV: leucovorin; Oxa: oxaliplatin;TRG:tumor regression grade; TNM: tumor node metastasis staging;DFS: disease-free survival; OS:overall survival;pCR: pathologic complete response; PR:partial pathologic response.