Patient |
CNS prophylactic treatment |
Time to CNS relapse (months) |
CNS curative treatment |
Graft |
Radiation therapy modality |
Delivered dose to CNS |
1 |
IT methotrexate, cytarabine, depomedrol |
20 |
IV methotrexate, cytarabine
IT liposomal cytarabine and corticosteroids
CSI |
No |
3D-CRT
6 MV photons |
18 Gy (10 fractions) + boost until 40 Gy to cerebral posterior fossa |
2 |
IT methotrexate, cytarabine, depomedrol |
103 |
IV methotrexate, cytarabine
IT methotrexate, cytarabine, depomedrol
CSI |
Yes |
IMRT
6 and 20 MV photons |
15 Gy (10 fractions) |
3 |
IT methotrexate, cytarabine, corticosteroids |
56 |
IV cyclophosphamide, methotrexate, doxorubicin, vincristine, cytarabine and dexamethasone
IT liposomal cytarabine
CSI |
No |
HT
6 MV photons |
23.4 Gy (13 fractions) |
4 |
No |
0 |
IV hydroxyurea, idarubicin, cytarabine,
Oral imatinib,
IT cytarabine (conventional then liposomal), methotrexate and corticosteroids
CSI |
No |
HT
6 MV photons |
23.4 Gy (13 fractions) |
CNS: central nervous system, IT: intrathecal, IV: intravenous, CSI: craniospinal irradiation, 3D-CRT: three dimensional conformal radiotherapy, IMRT: intensity-modulated
radiation therapy, HT: helical tomotherapy. |
