Parameters                                         Days Total F value P value 1 7 14 21 28 WBC x 109/L 5.43 4.37 3.49* 2.63* 2.77 3.73 7.142 0.000*** LYM x 109/L 3.08 3.47 2.97 2.25 2.32 2.81 2.557 0.051* LYM % 57.18 75.77 86.72 87.82 85.06 78.51 10.641 0.000*** GRAN 109/L 1.93 0.33* 0.14* 0.09 0.13 0.52 52.431 0.000*** GRAN % 35.72 7.58* 5.09 4.93* 5.97 11.85 88.547 0.000*** MID 109/L 0.42 0.57 0.38 0.29 0.32 0.39 1.977 0.114 ns MID % 7.18 10.65 8.19 7.25 8.9 7 8.44 1.083 0.376 ns RBC 1012/L 4.07 4.16 8.19 7.25 8.97 8.44 1.083 0.376 ns HGB 9/dl 11.85 12.13 11.82 12.11 12.14 4.13 0.171 0.952 ns HCT % 33.63 39.75 33.72 34.32 34.20 35.12 1.229 0.312 ns MCV F1 77.68 83.55 77.72 77.10 82.18 79.64 0.583 0.677 ns MCHC g/dl 35.26 35.00 35.22 35.37 35.59 35.28 0.904 0.470 ns MCH pg 29.18 28.46 29.14 29.02 29.23 29.00 0.403 0.805 ns RDW % 13.33 14.46 14.56 15.16 15.04 14.51 6.101 0.001*** RDWA FL 64.41 67.11 67.85 66.66 69.14 67.03 1.218 0.316 ns PLT 104/L 112.70 113.50 110.10 88.57 105.20 106.01 1.584 0.195 ns MPV FL 7.75 8.22 8.34* 8.48 8.92 8.34 6.27 0.000*** PDW FL 10.41 10.97 11.16 11.47 12.13 11.22 5.521 0.001*** PCT % 0.08 0.08 0.08 1.28 0.09 0.32 2.235 0.080 ns LPCR % 16.03 18.44 19.43 9.23 22.20 11.06 1.706 0.165 ns ESR mm/h 2.90 6.60* 5.60 2.80 2.50 4.08 3.714 0.011** * = Significant at P < 0.05 ** = Significant at P < 0.01 *** = Significant at P < 0.001 ns = Not significant

Table 1: Mean test of significance for all the days (haematological parameters).