Diagnosis Age*/Sex DAT Procedure Replacement Fluid Clinical Response Outcome Reference WAIHA Post-infectious† 40/M IgG+ C3+ Phlebotomy (900 mL) + Plasmapheresis (2400 mL) 2 pRBC 700 mL WB, 450 mL plasma 500 mL Haemaccel Rapid Improvement Afebrile Stable Hgb Decreased hemolysis Improved renal function Decreased DAT Survived Garelli [14] Refractory CLL WAIHA Volume overload 54/F IgG+ 2L WBEx using Infusion pumps Reconstituted RBC (saline, albumin, plasmalyte,plasma) Improvement Decreased DAT Survived Becker [15] WAIHA‡ 19/M IgG+ ± C3+ WBEx (4300 mL) WB Rapid improvement Decreased hemolysis Improved oxygenation Decreased DAT Survived This case SCID Haploidential-BMT IgM-WAIHA 0.9/F C3+ WBEx WB None Ongoing hemolysis Autoagglutination CVA x 2 Deceased Friedmann [4] Evan’s Syndrome IgM-WAIHA 9/F C3+ WBEx WB None Ongoing hemolysis Autoagglutination Multiple CVA Pulmonary emboli Renal failure Ischemic gangrene Deceased Nowak-Wegrzyn[5] Mycoplasma Anti-Pr cold AIHA 41/M C3+ WBEx WB None Deceased Schonitzer [16] BMT: Bone Marrow Transplantation; CVA: CerebroVascular Accident; CLL: Chronic Lymphocytic Leukemia; DAT: Direct Antiglobulin Test; SCID: Severe Combined Immuno Deficiency. * Age in years †Upper respiratory tract infection with fever in the last month. ‡Presumed post-infectious

Table 1: Use of whole blood exchange in AIHA.