| |
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma |
Nodal Marginal Zone Lymphoma (NMZL) |
Splenic Marginal Zone Lymphoma (SMZL) |
| Clinical Characteristics |
• Mostly present as localized disease
• Stomach is the most common site of involvement.
• Other typical site include other GI sites, salivary, ocular adnexa, thyroid, lungs, skin and breast
• Symptoms will depend on the location of the lesion
|
• Diffuse peripheral nodal involvement
|
• Splenomegaly and cytopenias
• Bone marrow is commonly involved
• Early satiety
• Abdominal bloating
|
| Morphology |
| Immunophenotype |
| Positive |
CD 19, 20, 22, 79a, IgG, BCL-2 |
| Negative |
CD 5, 10, 23, 103, Cyclin D1 and BCL6 |
| Associated Infections |
Helicobacter Pylori, C Jejuni, C. psittaci and B. burgdorferi |
Unknown |
Hepatitis C virus |
| Cytogenetic Abnormalities |
t(11;18) BIRC-MALT1
t(14;18) IGHV-MALT1
t(1;14) IGHV-BCL10
t(3;14) IGHV-FOXP1
del 6q TNFAIP3 |
No typical cytogenic aberration |
+3q
+12q |
