• Watchful waiting for favorable risk.
• Gastric MALT lymphoma with H Pylori should be treated for the infection.
• For non-gastric MALT lymphoma which is localized can be treated with involved field radiation therapy
• t(11;18) do not respond well to single alkylating agent
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• Watchful waiting for favorable risk
• Systemic treatment adapted from follicular lymphoma
• Rituximab alone
• Rituximab plus chemotherapy
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• Watchful waiting for favorable risk
• Initiating treatment for SMZL includes the following : progressive or painful splenomegaly and worsening cytopenia (Hgb<10g/dl, platelets <80K/ul or ANC <100/ul
• Concurrent hepatitis C virus infected patients may be treated with pegylated interferon and ribavirin.
• Splenectomy can lead to significant improvement of cytopenia for patients who are eligible for surgery
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