Classification Generic name FAERS MASE
Rank N EBGM Rank N PRR
Analgesic Meperidine N/A N/A N/A 28 32 3.9
AADS Adenosine 11 29 19.4 9 33 18.0
ABX, Beta-lactam Meropenem N/A N/A N/A 28 34 3.1
ABX, Cephalosporin Cefepime N/A 9 2.1 36 27 3.0
ABX, Cephalosporin Ceftriaxone N/A 20 1.3 34 33 3.1
ABX, Glycopeptide Vancomycin 30 109 6.8 20 162 4.7
AFP, Echinocandin Micafungin N/A 6 1.9 23 14 4.2
AFP, Polyene Amphotericin B 28 58 7.0 19 66 4.9
ANTI Leucovorin N/A N/A N/A 26 130 4.0
ANTI Methotrexate N/A 80 1.9 38 616 2.8
ANTI, ANT Doxorubicin 38 191 3.7 30 210 3.7
ANTI, Kinase Inh Temsirolimus 40 24 3.5 22 26 4.2
ANTI, Pt Carboplatin 39 151 3.7 24 188 4.1
ANTI, Pt Oxaliplatin 36 148 4.5 21 184 4.6
ANTI, pur Azathioprine N/A N/A N/A 17 226 5.8
ANTI, pur Clofarabine N/A 10 1.3 27 19 3.9
ANTI, pur Mercaptopurine N/A 12 1.4 16 63 5.9
ANTI, pyr Fluorouracil N/A 52 1.4 39 134 2.7
ANTI, Taxanes Docetaxel 41 119 3.5 31 127 3.2
ANTI, Taxanes Paclitaxel 32 247 5.6 18 287 5.7
ANTI, TOPO Inh Irinotecan N/A 33 1.6 32 76 3.1
Contrast Iohexol N/A 11 2.3 29 14 3.8
Enz Acetylcysteine 33 16 5.0 N/A 25.0 2.8
Enz, CHF Nesiritide 16 16 15.9 5 28 26.3
Enz, Gout Pegaspargase 42 15 3.2 10 10 10.6
Enz, Gout Pegloticase 1 34 90.4 N/A N/A N/A
Enz, GSD Agalsidase Beta 22 72 10.9 7 120 23.3
Enz, GSD Alglucosidase Alfa 13 71 19.2 N/A 2.0 52.9
Enz, GSD Galsulfase 26 23 7.9 3 26 45.0
Enz, GSD Idursulfase 5 91 34.5 1 20 103.8
Enz, GSD Imiglucerase 35 31 4.5 N/A 1.0 12.6
Enz, GSD Laronidase 25 32 7.9 N/A 3.0 48.5
Enz, GSD Velaglucerase Alfa 2 12 54.0 N/A N/A N/A
Enz, Pls α-1-Antitrypsin 8 36 24.0 N/A N/A N/A
FEN CaCl and KCl 7 34 26.6 N/A 8.0 1.7
FEN Phytomenadione 21 12 12.4 25 25 4.1
FEN, Fe Ferric Na Gluc 4 55 37.6 N/A N/A N/A
FEN, Fe Ferumoxytol 23 13 9.2 N/A N/A N/A
FEN, Fe Iron Dextran 3 68 48.1 2 66 48.9
FEN, Fe Iron Sucrose 6 57 27.0 N/A N/A N/A
FEN, Mg Mg sulfate N/A 6 3.2 37 28 2.9
IMiD C1 Esterase Inhibitor (Human) 24 17 8.0 N/A N/A N/A
IMiD Sipuleucel-T 15 19 17.0 N/A N/A N/A
IMiD, HMAB Belimumab 17 28 15.5 N/A N/A N/A
IMiD, HMAB Ofatumumab 18 23 13.5 N/A N/A N/A
IMiD, HMAB Panitumumab 29 47 6.8 14 45 7.1
IMiD, IG Abatacept 43 39 3.1 35 33 3.0
IMiD, IG Ig 14 314 17.4 12 68 9.0
IMiD, IG Rho-Ig 19 32 13.3 N/A N/A N/A
IMiD, MCABS, Chimeric Cetuximab 12 637 19.3 8 612 18.4
IMiD, MCABS, Chimeric Infliximab 9 4050 23.1 6 3100 25.7
IMiD, MCABS, Chimeric Rituximab 27 387 7.1 15 373 6.5
IMiD, MCABS, Humanized Gemtuzumab 10 121 19.7 4 128 27.0
IMiD, MCABS, Humanized Natalizumab N/A 374 1.7 40 338 2.4
IMiD, MCABS, Humanized Trastuzumab 37 65 3.8 N/A 8.0 1.5
IMiD, RMAB AntithymocyteIg 34 67 4.6 13 82 7.9
Other Albumin 20 25 12.7 N/A N/A N/A
Photosensitization Verteporfin 31 19 5.7 11 26 10.5
Abbreviations: AADS: Antiarrhythmic Drugs; AXB: Antibiotic; AFP: Antifungal; ANTI: Antimetabolite; ANT: Anthracycline; Ca: Calcium; Cl: Chloride; CHF: Congestive Heart Failure; Enz: Enzyme; FEN: Fluids/Electolytes/Nutrition; Gluc: Gluconate; GSD: Glycogen Storage Disease; HMAB: Human Monoclonal Antibodies; IG: Immunoglobulin; inh: Inhibitor; IMiD: Immunomodulatory Drug; Fe: Iron; Mg: Magnesium; Min: Mineral; MCABS: Monoclonal Antibodies; MMAB: Mouse Monoclonal Antibodies; Pt: Platinum; K: Potassium; Pls: Proteinase Inhibitor; PKI: Protein Kinase Inhibitor; pur: Purine; pyr: Pyrimidine; Na: Sodium; TOPO: Topoisomerase
Table 3: Drugs highly associated with infusion reactions from MASE (PRR>2.0 and N>10 reports) and FAERS (EBGM >2.0 and N>10 reports) are grouped by drug class and then displayed with rank as well as comparison data. EBGM is from FAERS and PRR is displayed from MASE as a statistical comparison and to improve the sensitivity of drug detection.