| Biomarker |
Baseline (mean ± SD) |
Peak time (unit) |
Peak value (mean ± SE) |
P value |
| HIF-2α expression |
1 ± 0.62 (normalized) |
1 (h) |
2.37 ± 0.54 |
<0.001 |
| HIF-2α DNA binding activity |
1 ± 0.46 (normalized) |
0.5 (h) |
1.45 ± 0.37 |
~0.02 |
| EPO mRNA |
1 ± 0.72 (normalized) |
6 (h) |
6.02 ± 0.82 |
<0.001 |
| Plasma EPO |
254.9 ± 305.4 |
6 (h) |
2587.6 ± 1127.6 |
<0.001 |
| Reticulocytes |
21.6 ± 2.6 |
2 (day) |
31.9 ± 6.5 |
<0.05 |
| Hemoglobin |
11.0 ± 0.9 |
2 (day) |
12.7 ± 0.7 |
<0.05 |
|
