Factors Neurological dysfunction Myocardial infarction Postoperative dialysis Age (EuroSCORE) 1.16 (0.97 - 1.39) 0.97 (0.83 - 1.14) 1.16 (1.00 - 1.33) Female 0.50 (0.23 - 1.11) 1.17 (0.63 - 2.16) 1.02 (0.60 - 1.75) Patient factors compa) 0.99 (0.83 - 1.19) 0.90 (0.73 - 1.10) 1.32 (1.17 - 1.48) Neurological dysfunction 3.10 (1.46- 6.57) 1.68 (0.73 - 3.86) 1.27 (0.61 - 2.62) S-creatinine >200 µmol/ L 0.92 (0.19 - 4.38) 0.40 (0.05 - 3.10) 8.21 (4.12 - 16.5) Preop. platelets inhibitors 0.57 (0.17 - 1.97) 0.73 (0.30 - 1.84) 0.55 (0.25 - 1.20) Euroscore Cardiac state 1.13 (0.94 - 1.37) 1.29 (1.13 - 1.49) 1.27 (1.12 - 1.44) Valve surgery 2.12 (1.09 - 4.12) 0.85 (0.47 - 1.52) 1.43 (0.84 - 2.45) Aortic surgery 3.57 (1.35 - 9.46) 2.05 (0.72 - 5.84) 0.98 (0.36 - 2.69) Other than aortic/valve/CABG 1.11 (0.41 - 3.01) 0.20 (0.05 - 0.88) 1.52 (0.80 - 2.89) Peroperative Aprotinin 1.10 (0.34 - 3.50) 1.27 (0.39 - 4.12) 3.42 (1.74 - 6.77) Perioperative NovoSeven 0.74 (0.09 - 6.30) 1.05 (0.12 - 8.89) 0.88 (0.20 - 3.99) Perioperative Fibrinogen 2.69 (1.24 - 5.87) 1.79 (0.79 - 4.05) 3.77 (2.02 - 7.03)

Table 3: Adjusted odds-ratio and 95% confidence limits of significant factors from Table 1. a) Patient factors comp (EuroSCORE) = total mean individual EuroSCOREfor chronic pulmonary disease, extra cardiac arteriopathy, previous cardiac surgery, active endocarditis and critical peroperative state.