Plasma storage Condition

Storage Time  (hour)

% of intended value ± % CV

2.5 (ng/mL)

750 (ng/mL)

---

0

100.0 ± 7.3

100.0 ±1.9

25°C

6

108.3 ± 0.8

100.9 ± 3.7

24

102.9 ± 4.9

97.7 ± 1.3

72

102.8 ± 2.3

99.2 ± 3.1

6

104.3 ± 11.8

97.4 ± 1.5

4°C

24

101.4 ± 2.5

98.3 ± 1.6

72

104.2 ± 0.2

100.6 ± 0.8

Freeze and Thaw 3x

---

102.8 ± 2.3

97.9 ± 1.1

|N = 3 for all sample storage conditions, except time = 0 where N = 6
Table 1: Acyclovir Stability in Plasma.