Gene Name Symbol Alias % neonatal PDA % neonatal mortality Reference Prostaglandin-endoperoxide synthase 1 Ptgs1 Cyclooxygenase-1 0   [12] Prostaglandin-endoperoxide synthase 2 Ptgs2 Cyclooxygenase-2 33 35 [12] Prostaglandin-endoperoxide synthase 2 Ptgs2 Cyclooxygenase-2 57 57 [13] Prostaglandin-endoperoxide synthase 2a Ptgs2   0 0 [13] Ptgs2 (-/-) and Ptgs1 (+/-)     74 79 [12] Ptgs2 (-/-) and Ptgs1 (-/-)     100 100 [12,14]   Prostaglandin E synthase   Ptges Microsomal prostaglandin E synthase-1   0     [62] Prostaglandin E receptor 4 Ptger4 PGE receptor EP4 >95 >95 [16-18] Solute carrier organic anion transporter family, member 2A1   Slco2a1   Prostaglandin transporter     100   [20] Hydroxyprostaglandin dehydrogenase 15-(NAD) Hpgd Prostaglandin dehydrogenase >95 >95 [21, 22] acyclooxygenase activity was inhibited without affecting peroxidase activity

Table 1: Summary of prostaglandin pathway mutant mouse models relevant to the ductus arteriosus.