| Tissue compartment |
TLR9$ |
| Control |
Antibiotic |
Gnotobiotic |
| Dome epithelial surface |
1.75 ± 0.25 |
1.50 ± 0.29 |
0.50 ± 0.28* |
| Villous epithelial surface |
1.75 ± 0.25 |
1.50 ± 0.29 |
0.75 ± 0.25* |
| Villous goblet cells |
0.50 ± 0.50 |
0 ± 0 |
0.25 ± 0.25* |
| Crypt epithelial surface |
0.50 ± 0.29 |
1 ± 0 |
0 ± 0 |
| Dome |
1.60 ± 0.24 |
1.20 ± 0.20 |
1 ± 0 |
| Corona |
1.20 ± 0.20 |
0.80 ± 0.37 |
0.80 ± 0.19 |
| Follicle |
1.33 ± 0.21 |
1.40 ± 0.24 |
1 ± 0 |
| Inter follicular area |
0.67 ± 0.21 |
0.60 ± 0.24 |
0.67 ± 0.21 |
*Data from 3 or 4 animals only as in some tissues epithelial layer was damaged.
$- Statistical differences between the control vs antibiotics, control vs gnotobiotic,
and antibiotic vs gnotobiotic groups were calculated and P-value of ≤0.05 was
considered significant. No significant differences in various compartments were
obtained as P-values between different treatments were ≥0.05. |
