Table 1

Mouse Models	Common features	Unique features	References
itk^-/-; itk^-/-rlk^-/- cbp^-/-; klf2^-/- β-catenin^-/-	CD8αβ⁺ TCRαβ⁺ CD44hi Ly6c⁺ CD122⁺ CXCR3⁺ Eomes⁺ Rapid TCR mediated IFN-γ production	Altered disease susceptibility* Reduced CD5 expression* IL-15 dependent* Selected by MHC class Ia or Ib on haematopoietic cells Development of memory-like T cells is SAP dependent* Elevated IL-4 producing PLZF⁺ cell population	[164] [165,166] [167,168] [67,72,169] [170] [66]
id3^-/-		Selection by TECs Development of memory-like T cells is SAP-dependent Elevated CD5 expression Susceptible to Sjogren’s disease Elevated IL-4 producing PLZF⁺ cell population	[69] [171,172] [69]
nfκb1^-/-		IL-15 independent No evidence of an elevated PLZF⁺ cell population Selected by MHC class Ia or Ib on haematopoietic cells Elevated CD5 expression Reduced intrathymic Sirpα^hi DCs	[57]
Balb/c		KLF13 dependent Altered disease susceptibility Wild-type mouse strain	[74] [75,76]

* Denotes features to be confirmed in CBP, KLF2 and β-Catenin deficient mice.

Table 1: Distinguishing features of memory-like CD8⁺ T cells in wild-type and mutant mouse models.