| |
HI |
AVINA |
CD4+ T cell Proliferation |
IFN-γ (pg/ml) |
IL-5 (pg/ml) |
| H1N1 |
pre |
post |
Responsea |
pre |
post |
Responseb |
pre |
post |
Responsec |
pre |
post |
Responsed |
pre |
post |
Responsed |
| LAIV-1 |
5 |
20 |
R |
52 |
199 |
R |
1.9 |
7.5 |
4.0 |
82 |
64 |
0.8 |
59 |
49 |
0.8 |
| LAIV-2 |
20 |
20 |
NR |
295 |
473 |
R |
2.1 |
4.4 |
2.1 |
106 |
261 |
2.5 |
48 |
23 |
0.5 |
| LAIV-3 |
80 |
160 |
NR |
60 |
140 |
R |
5.4 |
9.6 |
1.8 |
78 |
168 |
2.1 |
10 |
32 |
3.2 |
| |
| TIV-1 |
160 |
160 |
NR |
215 |
623 |
R |
4.8 |
7.5 |
1.6 |
204 |
178 |
0.9 |
14 |
15 |
1.1 |
| TIV-2 |
40 |
80 |
NR |
494 |
494 |
R |
3.4 |
6.8 |
2.0 |
812 |
650 |
0.8 |
7 |
9 |
1.3 |
| TIV-3 |
80 |
160 |
NR |
251 |
251 |
R |
1.7 |
2.1 |
1.2 |
369 |
348 |
0.9 |
11 |
164 |
14.4 |
| |
| H3N2 |
|
| LAIV-1 |
80 |
80 |
NR |
52 |
199 |
R |
1.4 |
7.5 |
5.5 |
26 |
40 |
1.5 |
20 |
36 |
1.8 |
| LAIV-2 |
<10 |
20 |
R |
98 |
134 |
R |
2.4 |
7.8 |
3.2 |
28 |
74 |
2.6 |
25 |
28 |
1.1 |
| LAIV-3 |
40 |
160 |
R |
55 |
240 |
R |
2.1 |
16.1 |
7.6 |
31 |
237 |
7.7 |
9 |
8 |
0.9 |
| |
| TIV-1 |
20 |
160 |
R |
148 |
672 |
R |
1.2 |
5.5 |
4.5 |
19 |
28 |
1.5 |
8 |
9 |
1.2 |
| TIV-2 |
320 |
320 |
NR |
193 |
195 |
NR |
4.0 |
16.2 |
4.1 |
1006 |
6927 |
6.9 |
16 |
33 |
2.0 |
| TIV-3 |
20 |
20 |
NR |
28 |
61 |
R |
6.5 |
14.3 |
2.2 |
1361 |
1217 |
0.9 |
14 |
8 |
0.6 |
aResponse is a 4-fold or greater increase in titer after vaccination. R denotes Responder; NR denotes Non-Responder.
bResponse is a statistically significant increase in the titer determined by non-linear regression analysis
cResponse is the proliferative index i.e. ratio of T cell proliferation after vaccination, to proliferation measured before vaccination
dResponse is the ratio of cytokine concentration measured in supernatants before and after vaccination |
