Cycle 1 Cycle 2 Cycle 3 Cycle 4 Treatment Regime Fixed Non fixed Fixed Non fixed Fixed Non fixed Fixed Non fixed N (patients in each Cycle) 73 63 73 63 57 37 40 25 Months to retreatment (Median and range) 6 (5-7) 15 (7-48) 6 (5-7) 15 (7-48) 6 (5-7) 16 (7-48) 6 (5-7) 20 (7-32)

Table 2: Shows number of patients treated per cycle in each retreatment group and the median and range for each course of treatment in each cycle.