| |
|
Clinical stage |
Histological grade |
Lymph node status |
Vascular embolization |
Perineural infiltration Recurrence |
| |
|
I – II |
III – IV |
Well differentiated |
Poor/moderated
differentiated |
Negative |
Positive |
No |
Yes |
No |
Yes |
No |
Yes |
| Cyclin A |
N |
30 |
84 |
88 |
24 |
48 |
55 |
58 |
44 |
55 |
46 |
75 |
39 |
| |
Mean |
8.49 |
9.53 |
8.62 |
11.18 |
9.50 |
10 |
9.25 |
9.82 |
8.88 |
10 |
9.99 |
7.84 |
| |
SD |
10.54 |
9.77 |
9.42 |
11.20 |
11.47 |
9.26 |
10.86 |
9.83 |
10.15 |
10.51 |
11.1 |
7.13 |
| |
P value |
0.376 |
|
0.311 |
|
0.349 |
|
0.543 |
|
0.551 |
|
0.788 |
|
| Cyclin B1 |
N |
34 |
99 |
103 |
27 |
56 |
65 |
69 |
50 |
64 |
54 |
87 |
46 |
| |
Mean |
12.61 |
14.16 |
13.01 |
16.73 |
15.23 |
13.20 |
12.72 |
15.32 |
14.67 |
12.70 |
14.51 |
12.37 |
| |
SD |
14.16 |
14.17 |
13.63 |
16.16 |
14.99 |
13.94 |
12.83 |
15.68 |
14.98 |
12.90 |
14.36 |
13.74 |
| |
P value |
0.517 |
|
0.287 |
|
0.533 |
|
0.626 |
|
0.540 |
|
0.224 |
|
| Cyclin D1 |
N |
34 |
99 |
104 |
26 |
56 |
65 |
68 |
51 |
64 |
54 |
87 |
46 |
| |
Mean |
33.60 |
40.34 |
37.77 |
42.66 |
33.96 |
44.63 |
38.18 |
41.05 |
38.49 |
40.28 |
38.42 |
38.98 |
| |
SD |
20.76 |
20.55 |
21.01 |
17.97 |
20.47 |
20.06 |
21.69 |
18.90 |
20.76 |
19.98 |
19.39 |
23.29 |
| |
P value |
0.084 |
|
0.264 |
|
0.006 |
|
0.298 |
|
0.534 |
|
0.876 |
|
| Topo IIA |
N |
34 |
99 |
103 |
27 |
57 |
64 |
68 |
51 |
64 |
54 |
87 |
46 |
| |
Mean |
23.13 |
25.16 |
23.23 |
28.92 |
25.27 |
24.29 |
26.21 |
24.60 |
26.51 |
24.37 |
24.40 |
25.11 |
| |
SD |
17.77 |
16.80 |
16.36 |
18.52 |
16.87 |
17.38 |
16.89 |
17.14 |
16.69 |
17.04 |
17.48 |
16.26 |
| |
P value |
0.456 |
|
0.163 |
|
0.693 |
|
0.562 |
|
0.402 |
|
0.613 |
|
| Ki-67 |
N |
33 |
99 |
102 |
27 |
56 |
65 |
69 |
50 |
64 |
54 |
86 |
46 |
| |
Mean |
33.70 |
31.61 |
31.88 |
32.80 |
33.23 |
31.37 |
33.34 |
31.64 |
33.71 |
31.02 |
32.09 |
32.22 |
| |
SD |
14.71 |
15.17 |
13.58 |
18.46 |
14.73 |
15.66 |
16.47 |
13.75 |
14.49 |
16.33 |
14.22 |
16.60 |
| |
P value |
0.457 |
|
0.806 |
|
0.420 |
|
0.919 |
|
0.265 |
|
0.956 |
|
| P16 |
N |
35 |
99 |
104 |
27 |
57 |
65 |
69 |
51 |
65 |
54 |
88 |
46 |
| |
Mean |
41.67 |
42.19 |
41.43 |
41.49 |
43.96 |
40.20 |
41.20 |
43.03 |
43.33 |
40.98 |
44.16 |
38.02 |
| |
SD |
23.77 |
23.10 |
23.55 |
21.44 |
25.24 |
22.27 |
23.58 |
23.84 |
24.40 |
22.40 |
23.01 |
23.24 |
| |
P value |
0.925 |
|
0.918 |
|
0.382 |
|
0.667 |
|
0.575 |
|
0.185 |
|
| P21 |
N |
28 |
87 |
90 |
23 |
47 |
58 |
57 |
45 |
57 |
45 |
75 |
40 |
| |
Mean |
15.64 |
11.90 |
12.37 |
15.29 |
13.34 |
12.21 |
10.90 |
14.03 |
12.83 |
11.32 |
13.93 |
10.71 |
| |
SD |
12.37 |
10.32 |
10.94 |
10.85 |
11.20 |
10.79 |
9.96 |
10.94 |
11.30 |
9.48 |
11.13 |
10.32 |
| |
P value |
0.142 |
|
0.189 |
|
0.668 |
|
0.129 |
|
0.639 |
|
0.124 |
|
| P27 |
N |
29 |
87 |
89 |
26 |
47 |
59 |
57 |
46 |
57 |
45 |
77 |
39 |
| |
Mean |
31.48 |
28.34 |
28.41 |
31.91 |
30.04 |
28.03 |
31.13 |
26.41 |
30.25 |
28.26 |
31.12 |
25.19 |
| |
SD |
17.70 |
19.22 |
18.70 |
19.67 |
18.00 |
19.46 |
17.03 |
20.24 |
18.75 |
18.10 |
19.35 |
17.31 |
| |
P value |
0.321 |
|
0.389 |
|
0.474 |
|
0.108 |
|
0.652 |
|
0.124 |
|
| P53 |
N |
30 |
80 |
90 |
26 |
48 |
60 |
58 |
47 |
58 |
46 |
77 |
41 |
| |
Mean |
49.00 |
46.28 |
45.47 |
52.27 |
49.33 |
48.53 |
49.87 |
46.94 |
46.36 |
50.24 |
48.77 |
43.60 |
| |
SD |
33.50 |
32.57 |
33.86 |
27.07 |
33.35 |
32.74 |
31.11 |
34.47 |
32.28 |
33.69 |
32.27 |
33.58 |
| |
P value |
0.462 |
|
0.389 |
|
0.961 |
|
0.709 |
|
0.596 |
|
0.432 |
|
| Rb |
N |
31 |
95 |
98 |
26 |
53 |
62 |
65 |
49 |
65 |
48 |
82 |
44 |
| |
Mean |
42.52 |
52.42 |
52.81 |
44.47 |
49.37 |
52.54 |
53.26 |
50.58 |
52.92 |
50.48 |
49.60 |
52.80 |
| |
SD |
25.94 |
24.35 |
24.17 |
25.87 |
25.26 |
24.28 |
25.64 |
23.80 |
24.39 |
25.27 |
23.91 |
26.61 |
| |
P value |
0.269 |
|
0.127 |
|
0.596 |
|
0.593 |
|
0.697 |
|
0.471 |
|
SD:standard deviation |
