| Disease |
Sample (patients & control) |
Pattern |
Origin |
Method |
Biomarkers |
Validation |
| HNSCC[41] |
8&8 |
USS |
WS |
2D-DIGE |
Beta fibrin
S100 calcium-binding protein transferrin
cofilin-1 |
Western
Blotting |
| LC/MS |
|
|
Cleft lip
and palate[42] |
31&20 |
USS |
WS |
MALDI-TOF/MS |
Arpc3 Dermokine |
|
| Gingivitis[43] |
10&10 |
USS |
WS |
LC/MS MALDI-TOF/MS |
Albumin Hemoglobin
Immunoglobulin
Keratins |
|
| OSCC[44] |
4&4 |
USS |
WS |
|
Myosin
Actin |
Western
Blotting |
| Chronic periodontitis[45] |
10&10 |
USS |
WS |
2D-DIGE MALDI-TOF/MS
nLC-MS/MS |
Immunoglobulin
Hemoglobin
Albumin
Cystatin |
|
| Dental caries[46] |
16&16 |
USS |
WS |
2DE
MALDI-TOF/MS |
Amylase
IgA
Lactoferrin |
|
| Sjögren’s syndrome[47] |
8&8 |
USS |
WS |
2DE
ESI-MS/MS |
Keratin
Albumin
2 actin isoforms |
|
| OSCC[48] |
35&51 |
USS |
WS |
|
IL-1B
IL-8
M2BP |
ELISA |
| Gastric cancer[40] |
23&18 |
USS |
WS |
MALDI-TOF/MS |
4 proteins (1472.78 Da, 2936.49 Da, 6556.81 Da, and 7081.17 Da) |
|
| Breast cancer[49] |
10&10 |
USS |
WS |
2D-DIGE |
CA6 |
Immunoblotting |
| Rheumatoid arthritis[50] |
20&20 |
USS |
WS |
2DE
MALDI-TOF/MS |
2 S100A
Apolipoprotein
a-1 |
Immunoblotting |
| Type Ⅰdiabetes[51] |
31&31 |
USS |
WS |
LC-ESI-MS |
S100A9
PRP-1/PRP-3 |
|
| TypeⅠdiabetes[15,52] |
15&5 |
USS |
WS |
iTRAQ
MALDI-TOF/MS
LC-MS/MS |
HbA1c
BPI
MMP-9 |
|
Type II
diabetes[53] |
40&10 |
USS |
WS |
LC-MS/MS |
5 metabolism proteins |
ELISA |
HNSCC: Head and Neck Squamous Cellcarcinoma; USS: Unstimulated Saliva; WS: Whole Saliva; OSCC: Oral Squamous Cellcarcinoma