| metabolites |
retention time |
P valuea |
A(normal) |
B(cancerb) |
Rc |
| lactic acid |
7.787 |
0.001 |
0.0278 ± 0.0038 |
0.0369 ± 0.0059 |
0.33 |
| glycerol |
13.253 |
0.001 |
0.0864 ± 0.0251 |
0.0358 ± 0.0158 |
-0.59 |
| butanedioic acid |
14.701 |
0.005 |
0.0191 ± 0.0035 |
0.0138 ± 0.0028 |
-0.28 |
| L-serine |
16.014 |
0.002 |
0.0009 ± 0.0001 |
0.0006 ± 0.0002 |
-0.33 |
| L-threonine |
16.832 |
0.008 |
0.0016 ± 0.0002 |
0.0010 ± 0.0008 |
-0.38 |
| malic acid |
20.084 |
0.033 |
0.0069 ± 0.0019 |
0.0046 ± 0.0020 |
-0.33 |
| citric acid |
29.589 |
0.003 |
0.1833 ± 0.0343 |
0.1166 ± 0.0478 |
-0.36 |
| hexadecanoic acid |
35.467 |
0.003 |
0.1402 ± 0.0202 |
0.1877 ± 0.0376 |
0.34 |
|
| aP values were calculated based on Mann-Whitney test (significance at P<0.05). bCancer group includes the non-metastasis group and the metastasis group. cR value was
calculated from the arithmetic mean values of each group. R=(B-A)/A. R with a positive value indicates a relatively higher concentration present in cancer group while a
negative value means a relatively lower concentration as compared to the normal. |
| Table 2a: List of different metabolites identified in normal control group and cancer group (metastasis and non-metastasis mice). |
