| metabolites | 
        retention    time | 
        P valuea | 
        A(non-metastasis) | 
        B(metastasis) | 
        Rb | 
       
      
        | glycerol | 
        13.253 | 
        0.046 | 
        0.0437 ± 0.0157 | 
        0.0278 ± 0.0119 | 
        -0.36 | 
       
      
        | butanedioic    acid | 
        14.701 | 
        0.046 | 
        0.0153 ± 0.0025 | 
        0.0124 ± 0.0024 | 
        -0.19 | 
       
      
        | L-serine | 
        16.014 | 
        0.006 | 
        0.0007 ± 0.0001 | 
        0.0005 ± 0.0002 | 
        -0.29 | 
       
      
        | L-threonine | 
        16.832 | 
        0.027 | 
        0.0014 ± 0.0008 | 
        0.0005 ± 0.0005 | 
        -0.64 | 
       
      
        | malic acid | 
        20.084 | 
        0.036 | 
        0.0055 ± 0.0018 | 
        0.0036 ± 0.0019 | 
        -0.35 | 
       
      
        | L-proline | 
        21.329 | 
        0.046 | 
        0.0101 ± 0.0040 | 
        0.0064 ± 0.0024 | 
        -0.37 | 
       
      
        | myo-inositol | 
        36.316 | 
        0.003 | 
        0.0062 ± 0.0013 | 
        0.0103 ± 0.0027 | 
        0.66 | 
       
      | 
  
  
    | aP values were calculated based on Mann-Whitney test (significance at P<0.05). bR value was calculated from the arithmetic mean values of each group. R=(B-A)/A. R with
a positive value indicates a relatively higher concentration present in metastasis group while a negative value means a relatively lower concentration as compared to the
non-metastasis. | 
  
  
    | Table 2b: List of different metabolites identified in metastasis and non-metastasis groups. |