metabolites retention time P valuea A(healthy controls) B(cancer) Rb
lactic acid 7.069 0.000 0.0022 ± 0.0002 0.0031 ± 0.0008 0.41
glycerol 12.373 0.038 0.0145 ± 0.0069 0.0086 ± 0.0054 -0.41
butanedioic acid 13.801 0.014 0.0005 ± 0.0001 0.0004 ± 0.0001 -0.20
L-serine 15.134 0.000 0.0014 ± 0.0004 0.0006 ± 0.0003 -0.57
L-threonine 15.938 0.002 0.0011 ± 0.0002 0.0006 ± 0.0004 -0.45
citric acid 28.678 0.026 0.0045 ± 0.0013 0.0034 ± 0.0012 -0.24
hexadecanoic acid 34.543 0.000 0.0665 ± 0.0075 0.1213 ± 0.0282 0.82
aP values were calculated based on Mann-Whitney test (significance at P<0.05). bR value was calculated from the arithmetic mean values of each group. R=(B-A)/A. R with a positive value indicates a relatively higher concentration present in cancer group while a negative value means a relatively lower concentration as compared to the healthy controls.
Table 3a: List of different metabolites identified in healthy controls and gastric cancer patients.