| Strategies for CCSCs eradication |
Effects observed |
References |
| CD44 silencing |
Apoptosis induction and tumor growth suppression |
[33,35] |
| Inhibition of IL-4 signalling |
Sensitization to chemotherapy |
[45] |
| Up-regulation of BMP4 |
Induction of differentiation |
[73] |
| Notch signaling impairment |
Decreased tumor growth, reduction in CCSCs frequency, and sensitization to irinotecan |
[74] |
| Hedgehog signaling impairment |
Proliferation impairment and apoptosis induction |
[76] |
| PI3K signaling impairment |
Inhibition of proliferation and apoptosis induction |
[76] |
| Curcumin assumption |
Growth inhibition, improvement of chemotherapy effects |
[77,78] |
| Sulforaphane assumption |
Tumor growth impairment |
[80,81] |
| Epigallocatechin-3-gallate assumption |
Impairment of CCSCs self-renewal |
[82] |
| Quercetin assumption |
Inhibition of colon cancer cell proliferation |
[83] |
| Treatment with N-BP |
Susceptibility to γδ lymphocyte clearance |
[91] |
