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| Table 2: Affymetrix protocol. The data generated from the Affymetrix® microarray analysis revealed that the differentiated, bone-matrix-producing hFOB1.19 osteoblasts affected the gene expression in PC-3 cells substantially more than the osteprogenitor-like, undifferentiated osteoblasts did. Interestingly, filtered GO-data showed showed specific gene classes which was affected by the co culture between PC-3 cells and differentiated osteoblasts. The genes belonging to the gene class are predominantly repressed by co-culturing, and the mainly classes positive regulate apoptosis and cell adhesion. |
