Table 4

Category	p-value*	Number of Genes#
Cancer	4.74E-09 - 1.82E-01	302
Gastrointestinal Disease	1.28E-05 - 1.82E-01	95
Reproductive System Disease	4.73E-05 - 1.82E-01	163
Genetic Disorder	2.46E-02 - 1.46E-01	96
Infectious Disease	1.23E-02 - 1.82E-01	6
Inflammatory Disease	1.23E-02 - 1.76E-01	52
Neurological Disease	1.23E-02 - 1.82E-01	46
Skeletal and Muscular Disorders	1.53E-02 - 1.76E-01	78
Dermatological Diseases and Conditions	1.88E-02 - 1.82E-01	30
Connective Tissue Disorders	3.06E-02 - 1.82E-01	84
Endocrine System Disorders	3.26E-02 - 1.82E-01	32
Inflammatory Response	3.26E-02 - 1.76E-01	29
Organismal Injury and Abnormalities	3.84E-02 - 1.35E-01	9
Hematological Disease	3.88E-02 - 1.81E-01	95
Renal and Urological Disease	4.71E-02 - 1.82E-01	26
Respiratory Disease	4.81E-02 - 1.46E-01	51
Immunological Disease	6.32E-02 - 1.82E-01	49
Hepatic System Disease	1.12E-01 - 1.12E-01	4
Developmental Disorder	1.20E-01 - 1.76E-01	10
Cardiovascular Disease	1.20E-01 - 1.82E-01	37
Metabolic Disease	1.50E-01 - 1.82E-01	12
Antimicrobial Response	1.76E-01 - 1.76E-01	3

*The ‘p-value’ was calculated using the right-tailed Fisher Exact Test and corrected for false discovery rate by the Benjamini-Hochberg method. Only those categories with a p value <0.05 are considered significant and therefore are presented. #The ‘number of genes’ represents the number of differentially expressed genes belonging to the specific IPA category in the Cr(VI) treated cells.

Table 4: IPA Classification of the Differentially Expressed Genes in the Cr(VI) treated Dermal Fibroblasts into Diseases and Disorders Categories.