Category

p-value*

Number of Genes#

Cholesterol Biosynthesis

2.14E-04

7

Oxidative stress response mediated by NRF2

1.50E-02

20

VDR/RXR activation

1.50E-02

11

p53 Signaling

3.38E-02

11

Hormone Receptor Regulated Cholesterol Metabolism

3.90E-02

3

Oxidative Stress

4.49E-01

5


*The ‘p-value’ was calculated using the right-tailed Fisher Exact Test and corrected for false discovery rate by the Benjamini-Hochberg method. Only those categories with a p value <0.05 are considered significant and therefore are presented.
#The ‘number of genes’ represents the number of differentially expressed genes belonging to the specific IPA category in the Cr(VI) treated cells.
Table 5: IPA Classification of the Differentially Expressed Genes in the Cr(VI) treated Dermal Fibroblasts into Toxicology Categories.