| STEPS |
CHARACTERISTICS |
| Loose of cell polarity |
Loose of E-cadherin (45)
Altered expression of integrins (46)
Increased expression of N-cadherin (49)
|
| Acquirement of motile properties |
Deregulation of polarity complexes such as Par 3, Par 6 and Scribble (49)
Decrease of membrane bound β-catenine and increase of cytosolic β-catenine (11-18)
Formation of reactive stroma through increased expression of chemokines (35-39)
|
| Degradation of ECM proteins |
Increased extracellular proteolysis
Imbalance between proteolytic mediators, corresponding receptors, and their specific inhibitors
|
