| Variables |
Arg/Arg |
Arg/Pro |
Pro/Pro |
Arg Allele frequency |
Pro Allele frequency |
Chi square |
p value |
| Gender |
|
|
|
|
|
|
|
| Males |
18(22.5) |
48(60.0) |
14(17.5) |
0.52 |
0.48 |
0.17 |
0.92 |
| Females |
4(20.0) |
13(65.0) |
3(15.0) |
0.53 |
0.47 |
|
|
| Age at diagnosis |
| <45 |
2(14.3) |
10(71.4) |
2(14.3) |
0.50 |
0.50 |
0.8 |
0.67 |
| >45 |
20(23.3) |
51(59.3) |
15(17.4) |
0.53 |
0.47 |
|
|
| TNM Stage |
|
|
|
|
|
|
|
| Early Stage
( I and II ) |
15(42.9) |
20(57.1) |
0(0.0) |
0.71 |
0.29 |
19.9 |
<0.0001 |
| Advanced Stage
( III and IV ) |
7(10.8) |
41(63.0) |
17(26.2) |
0.42 |
0.58 |
|
|
| Distant Metastasis |
| Positive |
3(10.7) |
8(28.6) |
17(60.7) |
0.25 |
0.75 |
52.7 |
<0.0001 |
| Negative |
19(26.4) |
53(73.6) |
0(0.0) |
0.63 |
0.37 |
|
|
| Histological type |
| ADC |
8(16.0) |
31(62.0) |
11(22.0) |
0.47 |
0.53 |
3.1 |
0.21 |
| SCC |
14(28.0) |
30(60.0) |
6(12.0) |
0.58 |
0.42 |
|
|
| Grade (ADC) |
| Well |
5(45.5) |
6(54.5) |
0(0.0) |
0.73 |
0.27 |
20.7 |
0.0004 |
| Moderately |
3(25.0) |
9(75.0) |
0(0.0) |
0.63 |
0.38 |
|
|
| Poorly Differentiated |
0(0.0) |
16(59.3) |
11(40.7) |
0.30 |
0.70 |
|
|
| Grade (SCC) |
| Well |
9(32.1) |
15(53.6) |
4(14.3) |
0.59 |
0.41 |
1.8 |
0.77 |
| Moderately |
4(28.6) |
9(64.3) |
1(7.1) |
0.61 |
0.39 |
|
|
| Poorly Differentiated |
1(12.5) |
6(75.5) |
1(12.5) |
0.50 |
0.50 |
|
|
| Smoking status |
| Non Smokers |
8(26.7 ) |
18(60.0) |
4(13.3) |
0.57 |
0.43 |
0.77 |
0.68 |
| Smoker |
14(20.0) |
43(61.4) |
13(18.6) |
0.51 |
0.49 |
|
|
| Current Smokers |
4(14.3) |
17(60.7) |
7(25.0) |
0.45 |
0.55 |
1.8 |
0.41 |
| Ex Smokers |
10(23.8) |
26(61.9) |
6(14.3) |
0.55 |
0.45 |
|
|
| Smoking Levels (Pack Year) |
| Mild (≤10) |
0(0.0) |
6(85.7) |
1(14.3) |
0.43 |
0.57 |
4.5 |
0.33 |
| Moderate (≤ 40) |
8(24.2) |
21(63.6) |
4(12.2) |
0.56 |
0.44 |
|
|
| Heavy (> 40) |
6(20.0) |
16(53.3) |
8(26.7) |
0.47 |
0.43 |
|
|
| Family history of any cancer |
| Significant |
3(16.7) |
11(61.1) |
4(22.2) |
0.47 |
0.53 |
0.64 |
0.73 |
| Non Significant |
19(23.2) |
50(60.9) |
13(15.9) |
0.54 |
0.46 |
|
|
|
