| |
CSCC patients n=143 n (%) |
Control group n=207 n (%) |
p#total |
p |
OR |
95%CI |
| rs3136176 |
| Genotype |
| [AA]
[AT]
[TT] |
78 (54.5)
50 (35.0)
15 (10.5) |
116 (56.0)
81 (39.2)
10 (4.8) |
ns1 |
referent |
| 0.71
0.06 |
0.92
2.23 |
0.58 – 1.45
0.95 – 5.22 |
| Allele |
| [A]
[T] |
206 (72.0)
80 (28.0) |
313 (75.6)
101 (24.4) |
|
0.29 |
0.83
1.20 |
0.59 – 1.17
0.86 – 1.69 |
| Dominant model |
| [AA] + [AT] vs. [TT] |
128 (89.5)
15 (10.5) |
197 (95.2)
10 (4.8) |
|
0.04 |
0.43
2.31 |
0.19 – 0.99
1.01 – 5.30 |
| Recessive model |
| [TT] + [AT] vs. [AA] |
65 (45.5)
78 (54.5) |
91 (44.0)
116 (56.0) |
|
0.78 |
1.06
0.94 |
0.69 – 1.63
0.61 – 1.45 |
| rs1799798 |
| Genotype |
| [GG]
[GA]
[AA] |
107 (74.8)
32 (22.4)
4 (2.8) |
162 (78.3)
42 (20.3)
3 (1.4) |
ns2 |
referent |
| 0.59
0.59* |
1.15
2.02 |
0.69 – 1.94
0.44 – 9.20 |
| Allele |
| [G]
[A] |
246 (86.0)
40 (14.0) |
366 (88.4)
48 (11.6) |
|
0.35 |
0.81
1.24 |
0.51 – 1.26
0.79 – 1.94 |
| Dominant model |
| [GG] + [GA] vs. [AA] |
137 (97.3)
4 (2.8) |
207 (98.6)
3 (1.4) |
|
0.59 |
0.50
2.01 |
0.11 – 2.25
0.44 – 9.14 |
| Recessive model |
| [AA] + [GA] vs. [GG] |
36 (25.2)
107 (74.8) |
45 (21.7)
162 (78.3) |
|
0.45 |
1.21
0.83 |
0.73 – 2.00
0.50 – 1.36 |
| OR – Odds Ratio
95%CI – 95% Confidence Intervals
^– p-value afterBonferroni correction
* – p-value after Yate’s correction
#– global p-value for genotype |
| rs3136176 |
rs1799798 |
| 1 - χ2= 4.217333, df= 2, p= 0.121508
HWECSCCpatients: χ2= 2.502273, p= 0.113745
HWEcontrols: χ2= 0.764352, p= 0.382012 |
2 - χ2= 1.072568, df= 2, p= 584951
HWECSCCpatients: χ2= 0.699073, p= 0.403135
HWEcontrols: χ2= 0.021731, p= 0.882812 |
