Control group G1 G2 G3   χ2 p OR 95%CI
ERCC4rs3136176 / ERCC4rs1799798
A A 45.89 (0.111) 11.00 (0.239) 22.98 (0.129) 5.00 (0.156) Control vs. G1 Control vs. G2 Control vs. G3 G1 vs. G2 G1 vs. G3 G2 vs. G3 6.204 0.378 0.588 3.437 0.795 0.173 0.012770 0.538724 0.443270 0.063750 0.795 0.677755 2.507 1.183 1.477 2.120 0.795 1.249 1.191 5.274 0.693 – 2.019 0.542 – 4.024 0.946 – 4.750 0.183 – 1.899 0.437 – 3.569
A G 267.11 (0.645) 22.00 (0.478) 105.02 (0.590) 14.00 (0.438) Control vs. G1 Control vs. G2 Control vs. G3 G1 vs. G2 G1 vs. G3 G2 vs. G3 5.153 1.823 5.691 1.861 0.126 2.570 0.023232 0.176953 0.017071 0.172506 0.722583 0.108888 0.497 0.780 0.422 0.637 0.849 0.540 0.269 0.917 0.544 – 1.119 0.204 0.872 0.332 – 1.221 0.343 – 2.102 0.253 – 1.155
T G 98.89 (0.239) 13.00 (0.283) 49.98 (0.281) 13.00 (0.406 Control vs. G1 Control vs. G2 Control vs. G3 G1 vs. G2 G1 vs. G3 G2 vs. G3 0.405 1.093 4.348 0.001 1.298 2.032 0.524449 0.295801 0.037069 0.980831 0.254545 0.154011 1.247 1.236 2.166 1.009 1.737 1.752 0.631 – 2.462 0.831 – 1.839 1.032 4.543 0.491 – 2.073 0.669 – 4.508 0.805 – 3.813
T A 2.11 (0.005) 0.00 (0.000) 0.02 (0.000) 0.00 (0.000)) Control vs. G1 Control vs. G2 Control vs. G3 G1 vs. G2 G1 vs. G3 G2 vs. G3 – – – – – – – – – – – – – – – – – – – – – – – –
Global result: total Control= 414.0, total G1= 46.0, total G2= 178.0, total G3= 32.0 Control vs. G1: χ2Global= 7.638241, df= 2 (frequency <0.03 in both control & G1 has been dropped), pFisher's= 0.022011, pPearson's= 0.021947 Control vs. G2: χ2Global= 1.823813, df= 2 (frequency <0.03 in both control & G2 has been dropped),pFisher's= 0.401824,pPearson's= 0.401758 Control vs. G3: χ2Global= 5.859575, df= 2 (frequency <0.03 in both control & G3 has been dropped),pFisher's= 0.053500,pPearson's= 0.053408 G1 vs. G2: χ2Global= 3.721821, df= 2 (frequency <0.03 in both G1 & G2 has been dropped),pFisher's= 0.155639,pPearson's= 0.155531 G1 vs. G3: : χ2Global= 1.565432, df= 2 (frequency <0.03 in both G1 & G3 has been dropped),pFisher's= 0.457219,pPearson's= 0.457219 G2 vs. G3: χ2Global= 2.685530, df= 2 (frequency <0.03 in both G2 & G3 has been dropped),pFisher's= 0.261217,pPearson's= 0.261123
Table 4: ERCC4 rs3136176 and ERCC4 rs1799798 haplotype frequencies in patients with cervical squamous cell carcinoma (CSCC) well (G1), moderately (G2) and poorly (G3) differentiated and healthy women.