| |
Target |
Experimental data |
Clinical data |
| Ab (Mabthera) |
CD20+ lymphocytes
Lymphoma |
+ |
+ |
| Immunotoxin (CAT-
3888, CAT- 8015)Antibody-drug conjugate (Brentuxi-mab) |
CD22+ lymphocytes
(Lymphoma, leukemia)
CD30+ lymphocytes
(Hodgkin lymphoma) |
+
+
|
(+)
(+)
|
| Ab (HER2/neu)
Toxin (orellanine) |
HER2+ tumor cells
Kidney cancer/tubulecells |
+
+ |
+
- |
| Radiotherapy |
lymph nodes/lymphoma
Hodgkin’s disease |
+ |
+ |
| Platinol |
Testicular cancer/
Teratoma |
+ |
+ |
| 6-OH DOPA |
Melanoma |
+ |
- |
| Ab (CTLA4) |
T cell function
Autoimmune reaction
Melanoma, lung, kidney cancer |
+ |
+ |
| Ab (PD-1) |
T cell function
Autoimmune reaction
Melanoma, lung, kidney cancer |
+ |
+ |
| T-cell (transplantation) |
Leukemia
(graft vs. host) |
+ |
+ |
