| MMP class |
MMP |
Enzyme name |
Molecular Weight (kDa) |
Substrates |
| Collagenases |
MMP-1 |
Collagenase - I |
57*
47 A |
Collagens (I, II, III, VII, and X), proteoglycans, entactin, ovostatin, MMP-2, MMP-9. |
| MMP-8 |
Collagenase-2/ neutrophil collagenase |
85*
64 A |
Collagens (I, II, III, VII, VIII and X), fibronectin, proteoglycans. |
| MMP-13 |
Collagenase-3 |
60*
48 A |
Collagens (I, II, III, VII, VIII and X), tenascin, plasminogen, aggrecan, fibronectin, osteonectin, MMP-9 |
| MMP-18 |
Collagenase-4 |
53*
51 A |
Type I collagen |
| Gelatinases |
MMP-2 |
Gelatinase-A |
72*
66 A |
Gelatin, collagen (IV, V, VII VI, IX and X), elastin, fibronectin. |
| MMP-9 |
Gelatinase-A |
92*
86 A |
Collagens (IV, V, VII, X, and XIV), gelatin, entactin, elastin, fibronectin, osteonectin, plasminogen, proteoglycans. |
| Stromelysins |
MMP-3 |
Stromelysin-I |
60*
52 A |
Collagens (IV, V, and IX), gelatin, aggrecan, laminin, elastin, casein, osteonectin, fibronectin, ovostatin, entactin, plasminogen. |
| MMP-10 |
Stromelysin2 |
53*
47 A |
Collagens (I, II, IV and V), gelatin, casein, elastin, fibronectin. |
| MMP-11 |
Stromelysin2 |
60*
47 A |
Collagens (IV, V, IX and X), laminin, elastin, fibronectin, casein, proteoglycans. |
| MMP-17 |
Homology tostromelysin-2 |
65*
63 A |
Pro-MMP2, fibrin/fibrinogen, gelatin. |
| Matrisylins |
MMP-7 |
Matrisylin |
28*
19 A |
Collagens IV, gelatin, fibronectin, laminin, elastin,
casein, transferrin. |
| MMP-26 |
Matrisylin-2 |
29 |
Collagen IV, fibronectin, fibrinogen, gelatin, pro-MMP9. |
| MT-MMP (membrane type-MMP) |
MMP-14 |
MT1-MMP |
66*
54 A |
Collagens (I, II, III), gelatin, fibronectin, laminin, vitronectin, entactin, pro-MMP2. |
| MMP-15 |
MT2-MMP |
76 |
Fibronectin, gelatine, vitronectin, entactin, laminin, pro-MMP-2 |
| MMP-16 |
MT3-MMP |
65*
63 A |
Collagen III, gelatin, casein, fibronectin, pro- MMP-2. |
| MMP-17 |
MT4-MMP |
65*
63 A |
Pro-MMP2, fibrinogen, gelatin. |
| MMP-24 |
MT5-MMP |
73 |
Fibronectin, pro-MMP2, proteoglycans, gelatin. |
| MMP-25 |
MT6-MMP |
62 |
Pro-MMP2, pro-MMP9, collagen IV, gelatine, fibronectin, Proteinase A. |
| Other enzymes |
MMP-12 |
Macrophage metalloelastase |
54*
45 A |
Collagen IV, gelatin, elastin, casein, fibronectin, vitronectin, laminin, entactin, fibrin/fibrinogen. |
| MMP-19 |
RASI I |
59 |
Collagen (I, IV) gelatin, fibronectin, laminin. |
| MMP-20 |
Enamelysin |
56 |
Amelogenin, aggrecan. |
| MMP-21 |
|
65 |
|
| MMP-22 |
|
58*
53 A |
|
| MMP-23 |
|
44 |
gelatin |
| MMP-27 |
|
59 |
|
| MMP-28 |
Epilysin |
59 |
|
*- Zymogen molecular weight, A active form molecular weight. |
