MMP/TIMP Expression level Cancer subtype Cell type Correlation with prognosis Reference MMP2 High - - Poor outcome [60] Positive T1-2 tumor - Shorter survival [61] High Lymph node-negative breast cancer - Shorter relapse-free survival [63] High - - Shorter survival [64] MMP9 High Lymph node-negative breast cancer - Shorter relapse-free survival [63] High - Cancer cells Longer relapse-free survival [65] Positive Estrogen receptor positive Stroma Shorter relapse-free survival and breast cancer-related survival Low Invasive ductal carcinoma - Shorter relapse-free survival [34] Positive Invasive ductal carcinoma Cancer cells Shorter relapse-free survival Positive Invasive ductal carcinoma Stroma (Fibroblast and MIC) Shorter relapse-free survival High Basal like - Shorter relapse-free survival [34] Positive Basal like Stroma (Fibroblast and MIC Shorter relapse-free survival Positive Luminal A Stroma (Fibroblast and MIC Shorter relapse-free survival MMP7 Positive Invasive ductal carcinoma Stroma (Fibroblast and MIC) Shorter relapse-free survival [34] MMP11 High - - Poor outcome [60] High Invasive ductal carcinoma - Shorter relapse-free survival [34] Positive Invasive ductal carcinoma Stroma (Fibroblast and MIC) Shorter relapse-free survival High Basal like - Shorter relapse-free survival [37] Positive Basal like Stroma (Fibroblast and MIC) Shorter relapse-free survival Positive Luminal A MIC Shorter relapse-free survival High Invasive breast carcinomas Cancer cells Worse disease outcome [71] Positive Invasive breast carcinomas Fibroblasts Adverse overall survival MMP13 Positive Basal like MIC Shorter relapse-free survival [99] Positive Luminal A Stroma (Fibroblast and MIC) Shorter relapse-free survival MMP14 Positive Invasive ductal carcinoma MIC Shorter relapse-free survival [34] Positive Luminal A MIC Shorter relapse-free survival 100 High - - Lymph node metastasis and/or lymph vessel invasion [67] TIMP1 High Invasive ductal carcinoma - Shorter relapse-free survival [34] Positive Invasive ductal carcinoma MIC Shorter relapse-free survival   TIMP2 High Invasive ductal or lobular carcinomas or both - Shorter relapse-free survival and shorter survival [73] High - - Shorter relapse-free survival [72] High     Shorter relapse-free survival [71] High - - Shorter relapse-free survival and shorter overall survival [70] High - - Shorter relapse-free survival and shorter overall survival [69] High Invasive ductal carcinoma - Shorter relapse-free survival [34] Positive Invasive ductal carcinoma Cancer cells Shorter relapse-free survival Positive Invasive ductal carcinoma Stroma (Fibroblast and MIC) Shorter relapse-free survival Positive Basal like Stroma (Fibroblast and MIC) Shorter relapse-free survival [100] Positive Luminal A Stroma (Fibroblast and MIC) Shorter relapse-free survival High Invasive ductal or lobular carcinomas or both - Shorter relapse-free survival [73] High   Stroma Shorter relapse-free survival [75] High - - Shorter relapse-free survival and shorter overall survival [74]

Table 2: Expression of MMPs and TIMPs and its relationship with clinical outcome of patients with breast cancer.