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Figure 1: Alignment of hemagglutinin (upper) and neuraminidase (lower) sequences. The H3N2 seasonal influenza strain (A/ Brisbane/10/2007) was selected as a standard for alignment. Dots indicate residues that are identical to the corresponding residues in H3N2, and dashes indicate deleted residues. Gray boxes indicate potential glycosylation sites, as predicted from the amino acid sequence. For HA, red residues represent the precursor cleavage site that links the functional HA1 and HA2 domains. Yellow residues indicates sites of loss the ability to bind RBCs. |