challenge virus

challenge route

time post infection

antigen

rVSV dose

rVSV route

species

viremia/ total

disease/total

survival/ total

reference

MA-ZEBOV

I.P

30 min

ZEBOV-GP

2x 10⁵ pfu

I.P

BALB/c mice

N.A

5/5

5/5

[21]

MA-ZEBOV

I.P

24 hrs

ZEBOV-GP

2x 10⁵ pfu

I.P

BALB/c mice

N.A

5/5

5/5

[21]

GPA-ZEBOV

I.P

1 hr

ZEBOV-GP

2x 10⁵ pfu

I.P

Guinea pigs

N.A

6/6

5/6

[21]

GPA-ZEBOV

I.P

24 hrs

ZEBOV-GP

2x 10⁵ pfu

I.P

Guinea pigs

N.A

6/6

3/6

[21]

MA-ZEBOV

I.P

0 min

ZEBOV-GP

1x 10⁵ pfu

I.P

Syrian hamsters

N.A

0/5

5/5

[24]

MA-ZEBOV

I.P

24 hrs

ZEBOV-GP

1x 10⁵ pfu

I.P

Syrian hamsters

N.A

0/5

5/5

[24]

MA-ZEBOV

I.P

48 hrs

ZEBOV-GP

1x 10⁵ pfu

I.P

Syrian hamsters

N.A

5/5

0/5

[24]

ZEBOV

I.M

20-30 min

ZEBOV-GP

2x 10⁷ pfu

I.M

Rhesus macaques

8/8

8/8

4/8

[21]

SEBOV

I.M

20-30 min

SEBOV-GP

2x 10⁷ pfu

I.M

Rhesus macaques

2/4

4/4

4/4

[35]

MARV Musoke

I.M

20-30 min

MARV-GP

1x 10⁷ pfu

I.M

Rhesus macaques

0/5

0/5

5/5

[33]

MARV Musoke

I.M

24 hrs

MARV-GP

2x 10⁷ pfu

I.M

Rhesus macaques

3/6

4/6

5/6

[34]

MARV Musoke

I.M

48 hrs

MARV-GP

2x 10⁷ pfu

I.M

Rhesus macaques

5/6

6/6

2/6

[34]