Immunization

Mean time to deathb

No. survivors/ Totalc

T teste Kaplan-Meierf
Medium 5.7±0.45 (n=5) 0/5 N/A N/A
PA 5.5±0.71 (n=5) 0/5 p=0.704 p=1.0000
PK 6.5±0.00 (n=5) 0/5 p=0.016 p<0.0001
PF N/Ad 0/5 N/A p<0.0001
PKF 6.5 (n=1) 4/5 N/A p<0.0001

rVSV

N/A

0/5

N/A p<0.0001
Table 2: Immunodominant peptide # 98 protects against a MA-ZEBOV challenge in micea. aGroups of Balb/C mice (n=5) were immunized subcutaneously with media, 50μg peptide with (PF) or without Freund’s (PA), or 50 mg of peptide conjugated to KLH, with (PKF) or without Freund’s (PF) on days 0, 28, and 56. The positive control group VSVΔG/ZEBOVGP (rVSV) were immunized intraperitoneally once on day 56 with 2X104 pfu/ml. The mice were challenged on day 84 with 1000 LD50 of MAZEBOV and their survival followed for 28 days. bData for all animals that died (number of animals that died are in parentheses). cSurvival rate on day 28 after challenge. dN/A: not applicable. eT test: compares mean time to death between the test group and media control fKaplan-Meier Survival Curve: compared the survival curves between the test group and media control.