| GROUPS |
RUFFLED FUR |
LETHARGY |
HUNCHED |
PARALYTIC SIGNS |
DEAD/
EUTHANIZED |
| Gn(3) |
5/5 |
3/5 |
2/5 |
0/5 |
3/5 |
| Gn-C3d(3) |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
| Rep-Gn(3) |
5/5 |
1/5 |
0/5 |
1/5 |
3/5 |
| Gn-C3d(2)/Rep-Gn(1) |
3/5 |
1/5 |
1/5 |
0/5 |
3/5 |
| MP 12(1) |
5/5 |
2/5 |
1/5 |
1/5 |
3/5 |
| DNA control (3) |
5/5 |
5/5 |
0/5 |
2/5 |
3/5 |
| Rep control (3) |
4/5 |
2/5 |
3/5 |
1/5 |
5/5 |
| Mock vaccinated |
3/5 |
2/5 |
2/5 |
0/5 |
5/5 |
Groups of 6-8 week old female Balb/c mice were immunized by the indicated vaccines
or appropriate controls were challenged by aerosolized RVFV ZH501. Postchallenge
mice were observed for indicated clinical signs of infection. Numbers
in the parentheses indicates the number of vaccinations and the numbers without
parentheses indicates the number of mice displaying indicated clinical profile out of
a total 5 animals per group. |
