Ambroxol HCl

Ambroxol HCl degradate

Guaifenesin

Guaicol

Validation parameters

PLS

PCR

PLS

PCR

PLS

PCR

PLS

PCR

(a) Predicted vs. known concentration

             

1- Slope

0.9795

0.9846

1.0282

1.0276

0.9935

1.0029

0.8840

0.9064

2- Intercept

0.1793

0.1374

-0.0917

-0.0886

0.4375

-0.0034

1.1865

0.9861

3- Correlation coefficient (r)

0.9988

0.9989

0.9991

0.9988

0.9987

0.9980

0.9988

0.9994

(b) Residual vs. actual concentration

0.141

0.144

0.123

0.127

1.005

1.184

0.497

0.525

± error in prediction

               

(c) RMSEP

0.031

0.025

0.019

0.020

0.251

0.117

0.085

0.095

Table 3: Summary of results obtained by applying the diagnostic tools for model validation of the chemometric methods.