HPLC

TLC-spectrodensitometry

PLS

PCR

Dosage form Compound Found ± RSD% Recovery % of Standard addition Found ± RSD% Recovery % of Standard addition Found ± RSD% Recovery % of Standard addition Found ± RSD% Recovery % of Standard addition
Mucosin Syrup B. No. 07662 Ambroxol HCl 101.77 ± 1.095 100.87 ± 0.723

100.32 ± 0.550

100.43 ± 2.075

100.45 ± 1.821

100.33 ± 0.578

100.70 ± 1.684

98.78 ± 1.072

Guaifenesin 100.45 ± 1.067 100.50 ± 0.693

101.18 ± 0.653

102.06 ± 1.681

99.82 ± 1.880

100.47 ± 0.850

99.96 ± 1.986

101.70 ± 0.173

Mucosin Capsules B. No. 10301 Ambroxol HCl 99.01 ± 0.856 100.05 ± 1.298

99.45 ± 1.941

99.57 ± 2.006

99.47± 0.82

100.06 ± 0.418

100.13 ± 0.92

100.50 ± 0.500

Ambroxol tablets B. No. 080078A Ambroxol HCl 99.71 ± 1.118 99.80 ± 1.997

99.34 ± 1.151

99.28 ± 1.731

100.13 ± 1.75

99.94 ± 0.587

100.80 ± 1.76

100.00 ± 1.00

Ambroxol drops B. No. 091111A Ambroxol HCl 101.30 ± 0.440 100.37 ± 1.354

99.87 ± 0.987

99.28 ± 1.303

101.37 ± 1.52

99.89 ± 1.018

102.03 ± 1.44

100.11 ± 1.018

Table 4: Quantitative determination of Ambroxol HCl and Guaifenesin in pharmaceutical dosage forms by the proposed methods and application of standard addition technique