| Disease |
Clinical Features |
Histology |
Direct Immunofluorescence (perilesional skin) |
Indirect
Immunofluorescence |
Antigen |
Chronic Bullous Disease of Childhood
(CBDC) |
“cluster of jewels” pattern, vesicles or bullae on perigenital area, extremities, trunk, face |
Subepidermal cavity with
neutrophils along the basement membrane
vacuolar degeneration,
eosinophils
may be present |
linear deposition of IgA along the basement membrane, rare associated deposits of IgG, IgM, and C3 |
negative in the majority of cases |
97-kDa,
120-kDa
antigen |
| Bullous Pemphigoid |
tense vesicles or bullae on erythematous base on the inner surface of the thighs, forearms, axillary folds,
palms, soles |
subepidermal cavity with an
inflammatory infiltrate, predominantly of
eosinophils |
linear deposition of C3 and IgG along the basement membrane |
linear deposition of C3 and IgG along the basement membrane |
230-kDa, 180-kDa |
| Dermatitis Herpetiformis |
pruritic papules and vesicles on the extensor surfaces of the limbs,
buttocks, shoulders, nape of
neck, scalps |
subepidermal cavity with
neutrophils in the dermal
papillae,
edema of the papillary dermis, eosinophils may be
present |
granular deposition of IgA in dermal papillae |
negative |
epidermal transglutaminase |
| Erythema multiforme |
Papules, vesicles, targetoid lesions on palms, soles, extremities, trunk, oral mucosa |
subepidermal blister with infiltrate of lymphocytes in the underlying dermis, a few eosinophils, the epidermis overlying the blister may show necrosis, apoptotic keratinocytes present in the epidermis adjacent to the blister |
negative |
negative |
- |
