Channel Inheritance Locus Gene Protein Function Percentage Reference SODIUM AD 3p21-p24 SCN5A Nav1.5 Loss 25%-30% [22] AD 3p22.3 GPD1-L glycerol-3-P-DH-1 Loss <1% [27] AD 19q13.1 SCN1B Navb1 Loss <1% [28] AD 11q24.1 SCN3B Navb3 Loss <1% [30] AD 11q23.3 SCN2B Navb2 Loss <1% [29] AD 17p13.1 RANGRF RAN-G-release factor Loss <1% [32] AD 3p14.3 SLMAP sarcolemma associated protein Loss <1% [34] POTASSIUM AD 11q13-q14 KCNE3 MiRP2 Gain <1% [36] AD 12p12.1 KCNJ8 Kv6.1 Kir6.1 Gain <1% [39] AD 15q24.1 HCN4 hyperpolarization cyclic nucleotide-gated 4 NA <1% [45] Sex-related Xq22.3 KCNE5 potassium voltage-gated channel subfamily E member 1 like Gain <1% [46] AD 1p13.2 KCND3 Kv4.3 Kir4.3 Gain <1% [47] CALCIUM AD 2p13.3 CACNA1C Cav1.2 Loss 1% [50] AD 10p12.33 CACNB2B voltage-dependent b-2 Loss 1% [50] AD 7q21-q22 CACNA2D1 voltage-dependent a2/d1 NA 1% [52] AD 19q13.33 TRPM4 transient receptor potential M4 Loss/Gain <1% [54]

Table 1: Genes related to Brugada Syndrome. AD, Autosomic Dominant; AR, Autosomic Recessive, NA, Not Available. (*) Asterisk means that BrS type 3 and 4 were described also associated to shorter QT.