| Classification |
Coagulation factor level
(VIII:C or IX:C) |
Clinical phenotype |
| Severe |
<0·01 IU/mL
(<1% of normal activity) |
Spontaneous soft tissue and musculoskeletal bleeding |
| Moderate |
0·01–0·05 IU/mL
(1–5% of normal activity) |
Bleeding into joints and
muscles after minor
injuries or after surgical intervention |
| Mild |
>0·05–0·40 IU/mL
(5–40% of normal activity) |
Post-operative and post-traumatic bleeding only |
