Saquinavir

Ritonavir

Indinavir

Nelfinavir

Amprenavir

Lopinavir

Atazanavir

Fosamprenavir

Tipranavir

Darunavir

Saquinavir

1.00

0.54

0.59

0.57

0.50

0.57

0.61

0.52

0.45

0.50

Ritonavir

0.54

1.00

0.51

0.44

0.52

0.59

0.55

0.55

0.52

0.55

Indinavir

0.59

0.51

1.00

0.53

0.45

0.52

0.54

0.46

0.42

0.45

Nelfinavir

0.57

0.44

0.53

1.00

0.45

0.52

0.47

0.46

0.40

0.46

Amprenavir

0.50

0.52

0.45

0.45

1.00

0.48

0.51

0.87

0.49

0.89

Lopinavir

0.57

0.59

0.52

0.52

0.48

1.00

0.55

0.48

0.41

0.49

Atazanavir

0.61

0.55

0.54

0.47

0.51

0.55

1.00

0.53

0.47

0.53

Fosamprenavir

0.52

0.55

0.46

0.46

0.87

0.48

0.53

1.00

0.53

0.81

Tipranavir

0.45

0.52

0.42

0.40

0.49

0.41

0.47

0.53

1.00

0.54

Darunavir

0.50

0.55

0.45

0.46

0.89

0.49

0.53

0.81

0.54

1.00

Table 1: Tanimoto similarity scores between usual ARVs extracted from HIV-PDI. High scores represent high similarities. Here compounds highly similar to amprenavir are highlighted in grey.