Figure 1: Effect of Nanoparticle Formulation of GMP-grade WHI-P131 on the Growth of Mammary Tumors in MMTV/Neu Transgenic Mice. WHI-P131 [NP] (100 mg/kg) treatment resulted in significant tumor regression within 2 weeks in the depicted tumors of mouse # 67191 (A and B) and # 67083 (C and D). Normalized post-treatment tumor volumes were 0.32 (Day 1 volume = 1726 mm3, Day 14 volume = 546 mm3) for mouse # 67191 and 0.35 (Day 1 volume = 837 mm3, Day 14 volume = 291 mm3) for mouse #67083.