Figure 1: SPARC expression is correlated with prostate cancer progression and metastasis. A. Immunohistochemical analysis of SPARC expression in a prostate cancer tissue microarray of a range of Gleason patterns. Representative staining of cores of Gleason Score 2-4 (upper left), Gleason Score 5-6 (upper right), Gleason Score 7-8 (lower left), and Gleason Score 7-8 (lower right). B. A summary of the expression quantitation in tumoral, stromal, and epithelial compartments scored in intensity from 0-3 and shown here as a single summed score from 0-7. C. Analysis of gene expression data originally obtained by Lapointe et al. illustrates that increasing SPARC expression correlates with increasing Gleason Grade.