Figure 2: Specific FD inhibit human MC compound 48/80- and somatostatin-induced degranulation in a dose dependent manner. Mast cells were incubated overnight with FD, washed and activated with increasing concentrations of compound 48/80 (A) or somatostatin (B). Mediator release was assessed as described in materials and methods. Figures are representative of three separate MC cultures with each condition performed in triplicate.