Isolated aortic rings from cholesterol-fed non-treated group showed a significant (p<0.05) decrease in the relaxant effect of acetylcholine (ACh) compared to the control group.
However, aliskiren-treated group significantly (*p<0.05) augmented relaxation responses to ACh compared to cholesterol-fed non-treated group (2)
Figure 1: shows % decrease in basal tone of aortic rings isolated from rats of all tested groups.